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. 2017 Sep 8;8:628. doi: 10.3389/fphar.2017.00628

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Copyright © 2017 Galieva, Mukhamedshina, Arkhipova and Rizvanov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of pathological and cellular reactions after contusive spinal cord injury in rats (A) and transplantation of native (C) or genetically modified vegf and gdnf genes hUCB MCs (B). The transplantation of genetically modified vegf and gdnf genes hUCB cells leads to a significant improvement in recovery of the motor function, provides for a better preservation of tissues, reduces glial scar formation and also induces prominent axonal sparing/regeneration in comparison to controls or native hUCB MC therapy.