Table 2.
Clinical trials using hUCB cells.
| Cell type | Condition | Method of delivery | Outcome | References |
|---|---|---|---|---|
| SPINAL CORD INJURY (SCI) | ||||
| hUCB-MCs | chronic complete SCI | transplantation into dorsal entry zones above and below the injury site | two participants had fiber bundles growing across the injury site | Zhu et al. (2016) |
| intraspinal transplantation | hUCB-MCs transplants plus locomotor training improved WISCI and SCIM | Zhu et al. (2016) ClinicalTrials. Identifier: NCT01046786NCT01354483 | ||
| acute and subacute SCI | intraspinal transplantation | No Study Results Posted | ClinicalTrials. Identifier: NCT01471613 | |
| hUCB-MSCs | chronic SCI | intrathecal transplantation | No Study Results Posted | ClinicalTrials. Identifier: NCT01873547 |
| subacute and chronic SCI | intrathecal transplantation | No Study Results Posted. This study is currently recruiting participants. | ClinicalTrials. Identifier: NCT02481440 | |
| NEURODEGENERATIVE DISEASES | ||||
| hUCB-MSCs | dementia of Alzheimer's type | intraventricular administrations | No Study Results Posted. Apparently, the researchers were able to determine the optimal dose of hUCB MSCs and the best method of their transplantation to patients. | ClinicalTrials. Identifier: NCT01297218 NCT02054208 |
| Alzheimer's Disease | intravenous transplantation | No Study Results Posted. | ClinicalTrials. Identifier: NCT01547689 | |
| Alzheimer's Disease | intravenous transplantation | No Study Results Posted. This study is not yet open for participant recruitment. | ClinicalTrials. Identifier: NCT02672306 | |
| Amyotrophic Lateral Sclerosis | intrathecal transplantation | No Study Results Posted. | ClinicalTrials. Identifier: NCT01494480 | |
| hUCB | Amyotrophic Lateral Sclerosis, Parkinson's Disease | it is not known | No Study Results Posted. | ClinicalTrials. Identifier: NCT02236065 |
| STROKE | ||||
| hUCB-MCs | chronic ischemic stroke | transplantation into brain tissue adjacent to the infracted site | No Study Results Posted. The study is still recruiting participants. | ClinicalTrials. Identifiers: NCT02433509 |
| acute ischemic stroke | intravenous transplantation | No Study Results Posted. This study is currently recruiting participants. | ClinicalTrials. Identifier: NCT01673932 | |
| CD34+ stem cells obtained from hUCB | chronic ischemic stroke | intercerebral implantation | No Study Results Posted. | ClinicalTrials. Identifiers: NCT01438593 |
| hUCB | stroke | it is not known | No Study Results Posted. | ClinicalTrials. Identifiers: NCT01884155 |
| perinatal arterial ischemic stroke | intravenous transplantation | No Study Results Posted. | ClinicalTrials. Identifier: NCT02460484 | |
| ischemic stroke | intravenous transplantation | No Study Results Posted. | ClinicalTrials. Identifiers: NCT02397018 | |
| ischemic stroke | intravenous transplantation | No Study Results Posted. | ClinicalTrials. Identifier: NCT03004976 | |