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. 2017 Sep 15;8:1131. doi: 10.3389/fimmu.2017.01131

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Copyright © 2017 Eissa, Hussein, Kermarrec, Grover, Metz-Boutigue, Bernstein and Ghia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chromofungin (CHR) directly maintains gene expression of tight junction (TJ) proteins and decreases interleukin (IL)-8 and IL-18 release from lipopolysaccharide (LPS)- and dextran sulfate sodium (DSS)-stimulated colonic cell line. Caco-2 cells were treated with 1% phosphate-buffered saline (PBS) or CHR (100 nmol/mL) or sCHR (100 nmol/mL) in medium for 24 h then challenged with LPS (1 µg/mL) or 5% DSS for additional 24 h. (A) IL-8 and IL-18. (B) Colonic mRNA levels of TJ proteins [claudin-1 (CLDN1), zonula occludens-1 (ZO1), E-cadherin (CDH1), occludin (OCLN)]. One-way ANOVA was used to analyze the data followed by multiple comparison tests. Data represent mean ± SEM (n = 6). ^# refers to significance compared to control groups. Each experiment repeated at least three times.