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. 2017 Aug 25;117(17):11570–11648. doi: 10.1021/acs.chemrev.7b00287

Figure 10.

Figure 10

(A) FPP synthase is a processive enzyme that catalyzes the coupling of IPP molecules to a growing isoprenoid chain. Condensation of DMAPP and IPP yields GPP. In the second round of the chain elongation reaction, (a) ionization of GPP yields an allylic cation that (b) undergoes condensation with a second molecule of IPP. The chain elongation product, bearing a tertiary carbocation at C3, undergoes stereospecific proton elimination (c) to yield FPP. Abbreviations: PP = diphosphate, PPi = inorganic pyrophosphate. Reproduced from ref (67). Copyright 1981 American Chemical Society. (B) Model of the precatalytic enzyme–substrate complex showing the intermolecular orientations of DMAPP and IPP required in the reaction catalyzed by FPP synthase. Reproduced from ref (54). Copyright 2006 American Chemical Society.