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Crystal structure of AfUbiA reveals the characteristic α fold of a class I terpenoid synthase, which exhibits pseudo-2-fold symmetry between transmembrane helices TM1–4 and TM5–8. Superposition of TM1–4 and TM5–8 clearly reveals their structural homology, suggesting gene duplication and fusion of a primordial 4-helix bundle precursor. Reprinted from ref (41). Creative Commons Attribution 4.0 International Public License, http://creativecommons.org/licenses/by/4.0/legalcode.
