Figure 26.

Stereoview showing that each isoprene synthase monomer adopts αβ domain architecture, in which the α domain (blue) contains the characteristic aspartate-rich (red) and NSE (orange) metal-binding motifs. The substrate analogue dimethylallyl-S-thiolodiphosphate (stick figure) and 3 Mg²⁺ ions (magenta spheres) are bound in the active site. The β domain has no known catalytic function. Reprinted with permission from ref (152). Copyright 2010 Elsevier.