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. 2017 Aug 25;117(17):11570–11648. doi: 10.1021/acs.chemrev.7b00287

Figure 39.

Figure 39

(A) Comparison of (+)-limonene synthase (blue) and (−)-limonene synthase (green) showing that most active site residues are conserved. Reproduced from ref (194). Copyright 2017 American Chemical Society. (B) Superposition of the (+)-limonene synthase-2-fluorogeranyl diphosphate complex (green) and the (−)-limonene synthase-2-fluorolinalyl diphosphate complex (salmon). Active site residues M458/I450 and N345/I336 of (−)-limonene synthase/(+)-limonene synthase appear to be the principal determinants of right-handed/left-handed helical conformations of the substrate leading to formation of the proper limonene stereoisomer. Reproduced from ref (195). Copyright 2017 American Chemical Society.