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. 2017 Aug 25;117(17):11570–11648. doi: 10.1021/acs.chemrev.7b00287

Figure 41.

Figure 41

Reaction sequence catalyzed by the monoterpene cyclase cineole synthase. The ionization-dependent class I cyclization reaction of GPP forming α-terpineol is followed by a second protonation-induced cyclization reaction to yield 1,8-cineole.