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(A) Cyclization mechanism of selinadiene synthase. (B) Crystal structure of selinadiene synthase complexed with a substrate analogue (yellow stick figure) showing active site helices and loops that undergo structural changes to accommodate the bound analogue (blue). The break in helix G (green) is oriented so as to stabilize carbocation intermediates through interactions with the helix dipole. Reprinted with permission from ref (271). Copyright 2014 Wiley-VCH.
