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Crystal structure of the epi-aristolochene synthase-farnesyl hydroxyphosphonate (FHP) complex. The substrate analogue (stick figure) binds in the active site in the α domain (orange); the β domain (blue) has no known catalytic function other than to provide the N-terminal polypeptide which helps to stabilize the active site in the closed conformation. Reprinted with permission from ref (37). Copyright 1997 AAAS.
