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Cyclization mechanisms of wild-type cyclooctatenol synthase (CotB2wt) and selected active site mutants that generate alternative cyclization products: cyclooctat-9-en-7-ol (1), 3,7,12-dolabellatriene (2), cembrane A (3), 3,7,18-dolabellatriene (4), 3,7-dolabellatrien-9-ol (5), cyclooctat-6-en-8-ol (6), cyclooctat-7-en-3-ol (7), and cyclooctat-1,7-diene (8). Reproduced from ref (369). Copyright 2017 American Chemical Society.
