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. 2017 Aug 25;117(17):11570–11648. doi: 10.1021/acs.chemrev.7b00287

Figure 73.

Figure 73

Biosynthesis of ent-kaur-16-ene, or simply ent-kaurene, in the soil bacterium Bradyrhizobium japonicum proceeds through two separate enzyme-catalyzed reactions. The first reaction is a class II protonation-initiated cyclization of GGPP to form ent-copalyl diphosphate (ent-CPP), catalyzed by ent-copalyl diphosphate synthase (ent-CPPS). The second reaction is a class I ionization-initiated cyclization of ent-CPP to form ent-kaurene, catalyzed by ent-kaurene synthase (ent-KS). Reprinted from ref (377).