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. 2017 Aug 25;117(17):11570–11648. doi: 10.1021/acs.chemrev.7b00287

Figure 75.

Figure 75

Catalytic mechanism of taxadiene synthase. Taxadiene undergoes subsequent biosynthetic modifications to yield the cancer chemotherapeutic drug Taxol. Reprinted with permission from ref (42). Copyright 2011 Macmillan Publishers Ltd.