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Human oxidosqualene cyclase is a monotopic membrane protein partially embedded in the membrane; helix 8 (green) is predominantly hydrophobic and anchors the protein in the membrane leaflet. Ordered detergent molecules and lipid fragments (blue and black stick figures) cluster around the membrane anchor, including the hydrophobic channel leading to the active site at the βγ domain interface. Reprinted with permission from ref (462). Copyright 2004 Macmillan Publishers Ltd.
