Figure 91.

(A) Structural changes triggered by the binding of the bisphosphonate inhibitor alendronate (stick figure) and 3 Mg²⁺ ions (magenta) to the N-terminal domain of geosmin synthase. The aspartate-rich and NSE metal-binding motifs are red and orange, respectively. (B) Stereoview showing metal coordination and hydrogen bond interactions in the geosmin synthase-alendronate complex (thin solid and dashed lines, respectively). Reproduced from ref (492). Copyright 2015 American Chemical Society.