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Osthole accelerated bone fracture healing in Cre-negative group compared with Bmp2Col2Cre group. X-ray radiographic analysis was performed on mice 7, 10, 14, 21 and 28 days after surgery. Clear fracture lines were found on radiographs at day 7-21 in Bmp2Col2Cre group, and were indistinguishable at day 10 and 14 in Cre-negative group. These data suggest that Bmp2 is required for Osthole to promote bone fracture healing. Red arrows indicate the fracture lines.
