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. 2017 Jul 18;13(8):1008–1018. doi: 10.7150/ijbs.19891

Figure 2.

Figure 2

Linker histone in the pathway of tumorigenesis. Linker histone can respectively bind with CHD8, PTEN and MTA1. H1 binding with CHD8 represses the transcription of p53. H1 normally binds PTEN to promote chromatin condensation and repress the transcription of oncogenes; yet mutated PTEN represses H1 binding and leads to the chromatin relaxation, and promotes the transcription of oncogene in tumor cells. Also, H1 binding with MTA1 alters the transcriptional activity of several genes. These changes might result in the tumorigenesis of the cells through different pathways.