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. 2017 Sep 3;13(8):1082–1091. doi: 10.7150/ijbs.20905

Figure 6.

Figure 6

Schema of expression dynamics of Wnt/β-catenin signaling during cap to secretory stages of DM3. Wnt read out genes (β-Catenin, Axin2, Lef1) were marked with red color, while Wnt inhibitor (Dkk1) was marked with blue color. The transition from light to dark colors corresponds to low to high expression levels. (A) Tooth development stages from dental lamina to root development: I thickening dental lamina; II bud stage; III cap stage; IV bell stage; V secretory stage; VI root development; (B) At E40, Wnt read out genes were localized in the primary enamel knot, while Dkk1 was localized in the periphery regions of dental papilla. (C) At E50, Wnt read out genes were localized in the secondary enamel knots and underlying mesenchyme, while Dkk1 was localized in the lower parts of dental papilla. (D) At E60, Wnt read out genes were mainly localized in the undifferentiated IEE, odontoblasts, and pre-odontoblasts, while Dkk1 was localized in the lower undifferentiated parts of dental papilla and pre-odontoblasts.