Table 2.
stage | tissues/cells | species | ||
---|---|---|---|---|
mouse | pig | human | ||
cap stage -bell stage | enamel knot / IEE | Wnt3, Wnt4, Wnt6, Wnt7b [24], Wnt5a [12], Wnt10a, Wnt10b [29], β-catenin [5], Axin2 [10], Lef1 [30] |
Wnt3a, Wnt5a, β-catenin, Axin2, Lef1 |
Wnt5a [31,32], Wnt3, Dkk1, Sostdc1 [32], β-catenin, Lef1, Tcf4 [32] |
dental papilla | Wnt5a [24,25], Dkk1 [11], Sostdc1 [33], β-Catenin [5], Axin2 [10], Lef1 [30], Tcf1 [34] |
Wnt5a, Dkk1, β-catenin, Axin2, Lef1, Tcf4 |
Dkk1, Sostdc1 [32], β-Catenin, Lef1, Tcf4 [32] |
|
secretory stage | ameloblast | β-Catenin [9], Axin2 [34] | Wnt3a, Wnt5a | |
odontoblast/ pre-odontoblast |
Wnt5a [25], Wnt11 [35], Dkk1 [11,14], β-Catenin [36], Axin2 [34] | Wnt5a, Dkk1, Lef1, Tcf4 |
Wnt5a [31] | |
dental papilla | Wnt11 [35], Dkk2, Dkk3 [34] | Wnt5a, Dkk1 |