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IWP-2 inhibits IL-36γ-induced downregulation of differentiation markers in HaCaT cells. Filaggrin, involucrin, keratin 1 and keratin 5 mRNA levels in HaCaT cells were assessed by real-time PCR. HaCaT cells were incubated with IL-36γ (100 ng/mL) for 24 h and 48 h in the presence or absence of IWP-2 (1 μM). ∗P < 0.05 vs. Control group; #P < 0.05 vs. IL-36γ group.
