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IWP-2 inhibits IL-36γ-induced upregulation of proinflammatory cytokines in HaCaT cells. IFN-γ, IL-1β and IL-6 levels of conditioned media were assessed by ELISA. Conditioned media were collected from HaCaT cells incubated with IL-36γ (100 ng/mL) for 24 h and 48 h in the presence or absence of IWP-2 (1 μM). ∗P < 0.05 vs. Control group; #P < 0.05 vs. IL-36γ group.
