Figure 3.

Parameter sensitivity analysis of clopidogrel acyl‐β‐D‐glucuronide hepatic uptake factor and its impact on pioglitazone AUC ratio. Gray bar corresponds to the observed AUC ratio of pioglitazone when coadministered with clopidogrel (Kim et al.).10 Simcyp virtual trial design: clopidogrel 300 mg was administered on day 1 at 8:00 am followed by 75 mg q.d. on days 2 and 3 at the same time. Pioglitazone 15 mg was administered on day 1 at 9:00 am. A population representative was used for the sensitivity analysis in Simcyp v14.1. [Color figure can be viewed at wileyonlinelibrary.com]