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. 2017 Jul 11;142(5):649–661. doi: 10.1111/jnc.14103

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© 2017 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Effect of HDAC1 activity on parvalbumin (pvalb) and brain‐derived growth factor (bdnf) gene expressions in the somatosensory cortex of mice. Histone deacetylation by HDAC1 in promoter regions of Pvalb and Bdnf genes during whisker deprivation results in the transcriptional repression of the genes. Parvalbumin (PV) and brain‐derived neurotrophic factor (BDNF) proteins are implicated in the maturation of inhibitory circuitry, thus affecting the critical period plasticity. Temporal knockdown of HDAC1 specifically recovers Pvalb and Bdnf gene expression through transcriptional activation during whisker deprivation.