Figure 1.

Flow chart of the study. Progress in patients enrolment, number of subjects who missed a follow‐up visit or dropped out are presented. A total of 1,275 subjects did not meet the inclusion criteria. Twenty‐four subjects did not wish to participate in the study. After treatment allocation, a total of 11 subjects did not attend the 12‐month follow‐up. One patient did not receive intervention because he did not show up at the appointments. One patient withdrew before treatment initiation. Nine patients dropped out because they did not want to attend the follow‐up visits. BPT, basic periodontal therapy; AM, antimicrobials; ITT, intention to treat