Table 2.
Population Pharmacokinetic Parameters for the Final Population Pharmacokinetic Model of CC‐292
| Pharmacokinetic Parameter | Estimate | Bootstrap Estimate (95%CI) | Shrinkage (%) |
|---|---|---|---|
| ka, h−1 | 0.974 | 0.97 (0.86‐1.11) | |
| V2/F, L | 158.0 | 156.4 (130.2‐187.8) | 8.54 |
| V3/F, L | 72.0 | 71.7 (61.4‐83.5) | |
| Q/F, L/h | 18.7 | 18.4 (15.3‐21.7) | |
| CL/F, L/h | 134.0 | 131.9 (109.0‐166.6) | 3.63 |
| Alag1, h | 0.427 | 0.428 (0.414‐0.439) | |
| Effect of sex on CL/F | 0.26 | 0.26 (0.09‐0.45) | |
| Effect of age on V2/F | 0.946 | 0.946 (0.592‐1.355) | |
| Interindividual variability | |||
| ω2 V2/F | 0.755 | 0.750 (0.526‐1.010) | |
| ωV2/F: ωCL/F | 0.328 | 0.321 (0.198‐0.461) | |
| ω2 CL/F | 0.317 | 0.306 (0.202‐0.454) | |
| Residual variability | |||
| HNP | 0.234 | 0.230 (0.180‐0.288) | 6.49 |
| Patients | 0.659 | 0.654 (0.537‐0.708) | 4.21 |
Alag1, absorption lag time; CL/F, apparent clearance; HNP, healthy normal study subject; ka, first‐order absorption rate constant; Q/F, apparent intercompartmental clearance between central and peripheral compartments; V2/F, apparent central compartment volume of distribution; V3/F, apparent peripheral compartment volume of distribution.