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. 2017 Mar 16;6(5):466–475. doi: 10.1002/cpdd.346

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© 2017 The Authors. Clinical Pharmacology in Drug Development Published by Wiley Periodicals, Inc. on behalf of The American College of Clinical Pharmacology

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Plasma concentrations of midazolam (a) and its metabolites 1‐OH‐midazolam (b) and 4‐OH‐midazolam (c) in healthy volunteers over time following administration with and without tenapanor. Data are presented as arithmetic mean (SD). Values below the lower limit of quantification (0.1 ng/mL) were included in calculations as 0 ng/mL. Midazolam: single oral dose of midazolam 7.5 mg syrup, day 1. Midazolam + tenapanor: concurrent single oral dose of midazolam 7.5 mg and tenapanor 15‐mg tablet in the morning, day 15.