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. 2017 May 26;102(4):688–700. doi: 10.1002/cpt.690

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© 2017 The Authors Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Distribution of the relative contributions of major cytochrome P450 (CYP) alleles in European, African, Asian, and American populations. Pie charts showing the relative contribution of common variants in CYP2A6 (a), CYP2B6 (b), CYP2C8 (c), CYP2C9 (d), CYP2C19 (e), CYP2D6 (f), CYP3A4 (g), and CYP3A5 (h) in five major populations. Only variants with a minor allele frequency in the respective population above 1% are shown, whereas all other variants analyzed in this study are summarized as “rare” (grey).