Table 2.
Clinical, MRI, Cognitive, and Quality of Life Characteristics of Patients in the Clinical/MRI Dissociation Groups
| LL/HD | HL/LD | ND | Unadjusted P‐Value | Adjusted P‐Value* | |
|---|---|---|---|---|---|
| Clinical Characteristics | |||||
| SP, PP/RR | 16/6 | 1/49 | 58/403 | <.0001 | <.0001 |
| MSSS | 5.33 ± 2.29 | 1.16 ± 1.13 | 2.54 ± 2.35 | <.0001 | <.0001 |
| MRI Characteristics | |||||
| BPF | .836 ± .046 | .853 ± .049 | .864 ± .048 | .011 | .068 |
| Total GD+ | 0 ± 0 | .98 ± 4.24 | .19 ± 1.03 | .0003 | .029 |
| Cognition/Quality of Life | |||||
| SDMT | 53.6 ± 14.3 (17) | 51.8 ± 12.7 (36) | 53.9 ± 11.5 (312) | .59 | .082 |
| CES‐D | 30.6 ± 6.2 (22) | 29.6 ± 8.1 (49) | 29.6 ± 8.5 (452) | .85 | .81 |
| MFIS | 33.7 ± 12.7 (18) | 21.0 ± 13.9 (41) | 27.0 ± 17.0 (364) | .017 | .059 |
| MSQOL‐54 PHC | 58.8 ± 17.6 (18) | 80.6 ± 12.8 (44) | 73.0 ± 17.9 (418) | <.0001 | .0004 |
| MSQOL‐54 MHC | 72.5 ± 14.8 (22) | 76.9 ± 17.5 (48) | 75.2 ± 17.7 (450) | .62 | .75 |
Data are presented as mean ± standard deviation. For Cognition/Quality of Life measures, the value in parentheses is the sample size of patients who contributed to the analysis. LL/HD = low lesion load/high disability group; HL/LD = high lesion load/low disability group; ND = nondissociated group; RR = relapsing remitting; PP = primary progressive; SP = secondary progressive; MSSS = Multiple Sclerosis Severity Scale; BPF = brain parenchymal fraction; GD+ = number of cerebral gadolinium‐enhancing lesions; SDMT = Symbol Digit Modalities Test; CES‐D = Center for Epidemiologic Studies Depression scale; MFIS = Modified Fatigue Impact Scale; MSQOL‐54 = Multiple Sclerosis Quality of Life‐54 instrument; PHC = physical health composite; MHC = mental health composite. * P‐values are from regression adjusting for age, disease duration, and gender.