Figure 3.

AChE single nucleotide polymorphisms (SNP)‐induced propagation of imbalanced miR‐608 network. As previously reported (Hanin et al. 2014; Lin et al. 2016), a SNP in the 3’‐UTR of AChE diminishes miR‐608 binding and regulatory effect, causing both significant elevation of brain acetylcholinesterase (AChE) activity and down‐regulation of other miR‐608 targets attributed to ‘unemployed’ miR‐608 molecules. These include the anxiety‐inhibiting CDC42, the inflammatory‐promoting IL6, and the neuronal transcription factor NACC1, with possibly complex effects over brain transcriptome and activity. Thick arrows represent an increase in positive or negative regulation, whereas stroked arrows represent diminished regulation.