Table 2.
Brain metabolites measured by proton magnetic resonance spectroscopy (1H‐MRS)
| Baseline (EFV) | Follow‐up (LPV/r) | Change | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | Mean | SD | n | Mean | SD | n | Mean | 95% CI | ||
| FC | Cho/Cre | 14 | 0.26 | 0.03 | 14 | 0.27 | 0.03 | 14 | 0.01 | −0.01, 0.02 |
| NAA/Cre | 14 | 1.8 | 0.27 | 14 | 1.96 | 0.35 | 14 | 0.16 | −0.13, 0.44 | |
| FWM | Cho/Cre | 13 | 0.25 | 0.05 | 11 | 0.3 | 0.07 | 11 | 0.03 | −0.02, 0.08 |
| NAA/Cre | 13 | 1.38 | 0.33 | 11 | 1.51 | 0.22 | 11 | 0.11 | −0.12, 0.33 | |
| BG | Cho/Cre | 9 | 0.22 | 0.09 | 9 | 0.23 | 0.04 | 8 | 0.04 | −0.02, 0.10 |
| NAA/Cre | 9 | 2.34 | 0.78 | 9 | 2.13 | 0.31 | 8 | 0.03 | −0.32, 0.38 | |
FC, frontal cortex (frontal grey matter); FWM, frontal white matter; BG, basal ganglia; Cho, choline; Cre, creatine; NAA, N‐acetylaspartate; CI, confidence interval; EFV, efavirenz; LPV/r, ritonavir‐boosted lopinavir; SD, standard deviation.