Table 2.
Examples of dendrimer-based nanosystems as vehicles for nucleic acid
| Polymer | Generation | Payload | Application | Modification | Reference |
|---|---|---|---|---|---|
| PAMAM | G4 | siBCL-2 | Ovarian cancer | Hydroxylated LHRH peptide | [76,77] |
| G1 | Replicon mRNA | Vaccine | 2-tridecyloxirane | [78] | |
| G4 | siBCL-2 | Ovarian cancer | PEG-PLL | [79] | |
| G4 | IFN-β | Malignant glioma | Arginine | [80] | |
| PPI | G5 | siBCL-2 | LHRH positive cancer | DTBP LHRH-PEG | [60] |
| G2 | pCN-Luci | Arginine | [58] | ||
| G3 | siBCL-2 | Lung cancer | Au nanoparticle | [81] | |
| PLL | G3-G6 | p-Luci | PEG | [82] | |
| G6 | siGAPDH siOCT1 | Gluconeogenesis | EndoPorter | [62] | |
| G6 | pCMV-Luc | Arginine | [83] |