Table 5.
Crude Fraction of Tubal Factor Infertility (TFI) Attributable to Chlamydia, by Race, Serologic Measure, and TFI Case Definition
| Serologic Measure used to Determine Chlamydia trachomatis Seropositivity | |||||||
|---|---|---|---|---|---|---|---|
| Case Definition (by Race) | N | Positive by Medac IgG MOMP PAF (95% CI) |
Positive by EB-ELISA (IgG1 or IgG3) PAF (95% CI) |
Positive by EB-ELISA IgG1 PAF (95% CI) |
Positive by EB ELISA IgG3 PAF (95% CI) |
Positive by Medac IgG MOMP or EB ELISA PAF (95% CI) |
Positive by Medac IgG MOMP and EB ELISA PAF (95% CI) |
| Black Race | |||||||
| HSG case definitiona | 107b | −1% (−48%, 31%) |
12% (−97%, 63%) |
−8% (−100%, 51%) |
−28% (−100%, 24%) |
15% (−97%, 68%) |
−2% (−47%, 30%) |
| Expanded case definitionc | 117b | −4% (−49%, 28%) |
3% (−100%, 55%) |
−13% (−100%, 44%) |
−21% (−100%, 26%) |
12% (−99%, 63%) |
−7% (−52%, 23%) |
| Laparoscopy case definitiond | 31 | 5% (−91%, 55%) |
57% (−82%, 87%) |
57% (−82%, 87%) |
20% (−88%, 70%) |
29% (−100%, 80%) |
22% (−39%, 61%) |
| Non-Black Race | |||||||
| HSG case definitiona | 620 | 8% (−1%, 17%) |
12% (1%, 22%) |
8% (−1%, 16%) |
14% (6%, 23%) |
11% (−3%, 23%) |
9% (2%, 16%) |
| Expanded case definitionc | 654 | 9% (0%, 17%) |
14% (5%, 24%) |
10% (2%, 18%) |
15% (7%, 23%) |
14% (3%, 26%) |
9% (3%, 16%) |
| Laparoscopy case definitiond | 138 | 20% (5%, 35%) |
20% (0%, 37%) |
13% (−1%, 27%) |
26% (10%, 40%) |
21% (−2%, 40%) |
20% (8%, 31%) |
PAF, population attributable fraction; CI, confidence interval; MOMP, major outer membrane protein; EB, elementary body; ELISA, enzyme-linked immunosorbent assay; HSG, hysterosalpingogram
TFI case=unilateral or bilateral fallopian tube blockage on HSG; Control=bilateral patent tubes and no other tubal abnormalities on HSG and no prior history of tubal ectopic pregnancy or surgery to repair blocked tubes
Medac IgG MOMP result was not available for one subject.
TFI case=unilateral or bilateral fallopian tube blockage or other tubal abnormalities on HSG, or prior history of tubal ectopic pregnancy, hydrosalpinx, or surgery to repair blocked tubes; Control=bilateral patent tubes and no other tubal abnormalities on HSG and no prior history of tubal ectopic pregnancy or surgery to repair blocked tubes
TFI case=laparoscopy showing evidence of tubal damage; Control=laparoscopy within one year of study showing no evidence of tubal damage