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. 2017 Aug 9;139(36):12466–12473. doi: 10.1021/jacs.7b04641

Figure 2.

Figure 2

Multivariate analysis of PZN analogues. (A) Visualization with targeted t-SNE clustering of the I7 library from a single experiment. Each point corresponds to a single mass spectrum, with each cluster surrounded by a 95% confidence ellipsoid. The N/A cluster contains spectra without observable peptide signals. The position of (B) each mutant or (C) N/A colony is mapped onto the optical image to aid mutant recovery. The three colonies highlighted in panel B are displayed in more detail in Figure 3.