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Serum concentration versus time curves from one animal representative of the average pharmacokinetic values after an iv bolus dose of 1.5 mg/kg iv (S)-MDPV (upper panels) and (R)-MDPV (lower panels) administration in female (left panels) and male (right panels) rats (n = 4–5 per group). Symbols denote observed concentrations. The best-fit solid lines were determined by model-dependent pharmacokinetic analysis. See Table 3 for the average PK values and statistical comparisons.
