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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Drug Alcohol Depend. 2017 Aug 8;179:347–354. doi: 10.1016/j.drugalcdep.2017.07.011

Table 1.

Pharmacokinetic parameters for (S)-, (R)-, and (R,S)-MDPV after 1, 3, and 5.6 mg/kg iv administration of (R,S)-MDPV in male and female rats. Results from the 1 mg/kg dosing lacked sufficient concentration-time points in the terminal elimination phase to permit an accurate calculation of a complete pharmacokinetic profile (see Figure 3). These data were not statistically compared to the other two dose groups. See supplemental files for more details of the statistical analysis.

(S)-MDPV (R)-MDPV (R,S)-MDPV
Dose and PK Parameter Female Male Female Male Female Male
1 mg/kg (R,S)-MDPV n = 6 n = 6 n = 6 n = 6 n = 6 n = 6
AUCInf (ng min/ml)/dosea 12740 ± 2771 15592 ± 3677 14219 ± 3134 17539 ± 4356 13471 ± 2944 16564 ± 4015
t1/2λz (min)b 38 ± 8 30 ± 3 38 ± 8 28 ± 4 38 ± 8 29 ± 3
ClT (ml/min/kg) 82 ± 18 67 ± 14 73 ± 16 60 ± 13 77 ± 17 63 ± 14
Vdss (l/kg) 2.2 ± 1.0 1.5 ± 0.4 1.8 ±0.8 1.2 ±0.3 2.0 ± 0.9 1.4 ± 0.3
Vd (l/kg) 4.9 ± 2.3 2.9 ± 0.4 4.4 ± 2.0 2.4 ± 0.3 4.6 ± 2.1 2.6 ± 0.4
3 mg/kg (R,S)-MDPV n = 5 n = 6 n = 5 n = 6 n = 5 n = 6
AUCInf (ng min/ml)/dosea 19291 ± 3272 16715 ± 3359 23038 ± 3825 18447 ± 3389 20673 ± 3400 17321 ± 3015
t1/2λz (min)b 94 ± 29 118 ± 48 91 ± 33 117 ± 47 104 ± 29 119 ± 47
ClT (ml/min/kg) 53 ± 9 62 ± 12 44 ± 7 56 ± 10 48 ± 8 59 ± 10
Vdss (l/kg) 2.2 ± 0.8 2.8 ± 1.0 1.8 ± 0.7c 2.3 ± 0.7 2.0 ± 0.7c 2.6 ± 0.8
Vd (l/kg) 7.9 ± 3.4 11.9 ± 4.5 6.4 ± 2.3 10.5 ± 3.7 8.1 ± 2.9 11.2 ± 3.7
5.6 mg/kg (R,S)-MDPV n = 6 n = 5 n = 6 n = 5 n = 6 n = 5
AUCInf (ng min/ml)/dosea 19535 ± 5124 20040 ± 4456 22981 ± 6109 21989 ± 5092 21255 ± 5604 21022 ± 4774
t1/2λz (min)b 106 ± 21 88 ± 22 107 ± 19 89 ± 20 106 ± 19 88 ± 20
ClT (ml/min/kg) 54 ± 13 53 ± 15 46 ± 11 48 ± 14 50 ± 12 50 ± 15
Vdss (l/kg) 1.7 ± 0.4 2.4 ± 0.9 1.3 ± 0.3c 2.1 ± 0.8 1.5 ± 0.4c 2.3 ± 0.8
Vd (l/kg) 8.3 ± 1.6 7.2 ± 3.4 7.1 ± 1.4 6.6 ± 3.0 7.6 ± 1.4 6.9 ± 3.2
a

Calculated by dividing AUCInf by enantiomer dose for (S)- and (R)-MDPV (i.e., 0.5, 1.5, 2.8 mg/kg) or by total dose for (R,S)-MDPV (i.e., 1, 3, 5.6 mg/kg) dose administered.

b

Harmonic mean and pseudo standard deviation (Lam et al., 1985).

c

Significantly different from males (p<0.05).