Table 2.

Pharmacokinetic parameters for (S)-, (R)-, and (R,S)-MDPV after 3 mg/kg ip administration of (R,S)-MDPV in female (n = 5) and male (n = 6) rats. The T_max was 5 min in all cases. This was also the first measured time point after dosing. Figure 4 shows a representative concentration-time plot after the 3.0 mg/kg ip dose in a male and female rat. See supplemental files for more details of the statistical analysis.

3 mg/kg (R,S)-MDPV	(S)-MDPV		(R)-MDPV		(R,S)-MDPV
PK Parameter	Female	Male	Female	Male	Female	Male
t1/2λz (min)a	110 ± 51	78 ± 25	114 ± 45	80 ± 23	111 ± 48	74 ± 29
Cmax (ng/ml)	265 ± 82	496 ± 218	284 ± 90	527 ± 249	549 ± 159	1024 ± 463
Bioavailability (F)	0.36 ± 0.02b	0.60 ± 0.22	0.32 ± 0.03	0.55 ± 0.23	0.34 ± 0.03b	0.57 ± 0.22

^aHarmonic mean and pseudo standard deviation.

^bSignificantly different from male rats (p < 0.05).