Table 3.

Serum pharmacokinetic parameters after a 1.5 mg/kg iv dose of (S)-MDPV or (R)-MDPV in female and male rats. Also, see the representative concentration-time plots in Figure 3. Note that the single enantiomer dose of 1.5 mg/kg is equivalent to its respective enantiomer in a 3 mg/kg (R,S)-MDPV dose. See supplemental files for more details of the statistical analysis.

	(S)-MDPV		(R)-MDPV		S/R ratio
Dose and PK Parameter	Female	Male	Female	Male	Female	Male
1.5 mg/kg (R,S)-MDPV	n = 5	n = 4	n = 5	n = 4	n = 5	n = 4
AUCInf (ng min/ml)/dosea	14989 ± 1831	20108 ± 10088	20935 ± 5079	16492 ± 7447	0.74 ± 0.17 b	1.30 ± 0.45
t1/2λz (min)c	84 ± 20	95 ± 29	91 ± 31	121 ± 66	0.97 ± 0.39	0.76 ± 0.21
ClT (ml/min/kg)	67 ± 8	57 ± 19	50 ± 12	72 ± 33	1.40 ± 0.34	0.87 ± 0.40
Vdss (l/kg)	3.4 ± 1.6d	1.9 ± 0.7	1.6 ± 0.6	2.7 ± 1.1	2.06 ± 0.52 b	0.74 ± 0.25
Vd (l/kg)	8.8 ± 2.9	8.9 ± 4.3e	7.0 ± 2.7f	15.4 ± 8.3	1.38 ± 0.70	0.60 ± 0.07

^aCalculated by dividing AUC_Inf by the 1.5 mg/kg (S)- or (R)-MDPV dose.

^bSignificantly different (p < 0.05) from the male S/R ratio value.

^cHarmonic mean and pseudo standard deviation.

^dSignificantly different (p < 0.05) from the (R)-MDPV Vd_ss values within females.

^eSignificantly different (p < 0.05) from the (R)-MDPV Vd values within males.

^fSignificantly different (p < 0.05) from male (R)-MDPV Vd values.