Table 4.
S/R enantiomer ratios in female and male rats after administration of 3 and 5.6 mg/kg doses of (R,S)-MDPV. PK data for this analysis was derived from Table 1. See supplemental files for more details of the statistical analysis.
| Pharmacokinetic Parameter | Female | Male |
|---|---|---|
| 3 mg/kg (R,S)-MDPV |
S/R Ratio n = 5 |
S/R Ratio n = 6 |
| AUCinf | 0.84 ± 0.05a | 0.90 ± 0.05 |
| t1/2λz | 1.12 ± 0.40 | 1.03 ± 0.23 |
| ClT | 1.20 ± 0.08a | 1.11 ± 0.05 |
| Vdss | 1.25 ± 0.16 | 1.17 ± 0.15 |
| Vd | 1.28 ± 0.45 | 1.15 ± 0.28 |
| 5.6 mg/kg (R,S)-MDPV | n = 6 | n = 5 |
| AUCinf | 0.85 ± 0.03a | 0.91 ± 0.02 |
| t1/2λz | 0.99 ± 0.11 | 1.00 ± 0.06 |
| ClT | 1.18 ± 0.04a | 1.10 ± 0.02 |
| Vdss | 1.27 ± 0.08 | 1.16 ± 0.05 |
| Vd | 1.17 ± 0.12 | 1.09 ± 0.07 |
a
Significantly different (p < 0.05) from male values.