Skip to main content
. Author manuscript; available in PMC: 2017 Dec 12.
Published in final edited form as: Nat Genet. 2017 Jun 12;49(11):1584–1592. doi: 10.1038/ng.3888

Figure 3. Protein-protein-interaction subnetworks identified by the heat diffusion algorithm HotNet2.

Figure 3

The genes most strongly related to insomnia (P < 0.1) in the full and sex-specific GWGASes were used as input to investigate the enrichment of protein-protein interaction networks. Each node (protein) is assigned a score based on the gene P value of the GWGAS. The scores, denoted as “heat” in HotNet2, diffuse across the edges of the network. We report subnetworks that include genes with a wide range of heat scores: red colored nodes send and receive a significant amount of heat, while blue colored nodes do not. (a) Subnetwork identified for females including MEIS1. (b) Subnetwork identified for females including GNAS. Other identified subnetworks for females and males are shown in Supplementary Figure 18.