Table 2. Genome-wide significant genes associated with insomnia complaints in a GWGAS including 113,006 individuals and the sex-specific GWGASes.
| FULL |
MALE |
FEMALE |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol | Entrez ID | Chr | Start BPa | Stop BPa | N SNPs | P | P corr | N SNPs | P | P corr | N SNPs | P | P corr |
| DCBLD1 | 285761 | 6 | 117,801,803 | 117,892,021 | 384 | 4.54E-07 | 0.0083 | 385 | 0.0856 | 1 | 386 | 7.12E-06 | 0.131 |
| MEIS1 | 4211 | 2 | 66,660,257 | 66,800,891 | 426 | 6.60E-07 | 0.0121** | 424 | 7.56E-03 | 1 | 428 | 3.58E-04 | 1 |
| MED27 | 9442 | 9 | 134,734,497 | 134,957,274 | 608 | 7.81E-07 | 0.0143* | 608 | 9.56E-03 | 1 | 603 | 5.41E-04 | 1 |
| HHEX | 3087 | 10 | 94,447,681 | 94,456,408 | 19 | 2.49E-03 | 1 | 19 | 1.71E-06 | 0.031** | 19 | 0.5832 | 1 |
| RHCG | 51458 | 15 | 90,013,638 | 90,041,799 | 35 | 1.15E-04 | 1 | 34 | 2.19E-06 | 0.040** | 35 | 0.7115 | 1 |
| IPO7 | 10527 | 11 | 9,404,169 | 9,470,674 | 241 | 7.80E-04 | 1 | 234 | 0.7839 | 1 | 245 | 1.67E-06 | 0.031** |
| TSNARE1 | 203062 | 8 | 143,292,441 | 143,486,543 | 1083 | 0.029503 | 1 | 1074 | 0.9498 | 1 | 1079 | 1.76E-06 | 0.032** |
Gene-based P values are reported for all genes significant after Bonferroni correction (α = 2.72E-06) in at least one of the three analyses (full, males, females). Bold P values are significantly associated with insomnia. Gene association results in the deCODE sample and the meta-analysis are reported in Supplementary Tables 12 and 14. GWGAS, genome-wide gene-association study; Chr, chromosome; BP, base pair; P corr, P corrected for multiple testing.
a
reported on GRCh37, Including a window of 2,1 kb.
*
Genome-wide significant in in the combined analysis of UK Biobank and deCODE.
**
Stronger association signal in the combined analysis of UK Biobank and deCODE.