Figure 8.

Biodistribution and circulation time of HCSs. (A) Cy5.5-labeled HCSs were prepared and i.v. injected into the Eca109 tumor-bearing mice, and the whole mouse body was scanned using an in vivo imaging system. The (B) circulation time and (C) quantity of Dox in peripheral blood were analyzed at different time points after HCS–Dox administration. (D) Distribution of Dox in different organs of the mice including liver, spleen, heart, lung, kidney, brain, and tumor tissues. *p<0.05; **p<0.01.

Abbreviations: HCS, hollow carbon sphere; i.v., intravenously; Dox, doxorubicin.