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. 2017 Sep 11;12:6735–6746. doi: 10.2147/IJN.S140992

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© 2017 Zhao et al. This work is published and licensed by Dove Medical Press Limited

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Therapeutic efficacy of FA-PPLNPs/Mtx, PPLNPs/Mtx, and free Mtx in AIA rats.

Notes: (A) Clinical scores of rheumatoid arthritis as a function of days after induction (arrows, FA-PPLNPs/Mtx, PPLNPs/Mtx, free Mtx, or saline); (B) paw thickness after all treatments, measured with caliper; (C) AIA rat paws from the different groups. Values are mean ± SD (n=5, **P<0.01).

Abbreviations: FA-PPLNPs/Mtx, methotrexate-loaded folic acid–polyethylene glycol–poly(lactic-co-glycolic acid)–poly(cyclohexane-1,4-diylacetone dimethylene ketal)–lipid nanoparticles; AIA, adjuvant-induced arthritis.