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(A) Hind paws of AIA rats imaged by X-ray; (B) histological examination in ankle joints of normal rats and AIA rats treated with various formulations.
Abbreviations: AIA, adjuvant-induced arthritis; FA-PPLNPs/Mtx, methotrexate-loaded folic acid–polyethylene glycol–poly(lactic-co-glycolic acid)–poly(cyclohexane-1,4-diylacetone dimethylene ketal)–lipid nanoparticles.
