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. 2017 Sep 11;12:6735–6746. doi: 10.2147/IJN.S140992

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© 2017 Zhao et al. This work is published and licensed by Dove Medical Press Limited

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Serum concentrations.

Notes: TNFα (A) and IL6 (B) from normal rats and AIA rats treated with Mtx solution, PPLNPs/Mtx, and FA-PPLNPs/Mtx. Values are mean ± SD (n=3, **P<0.01, ***P<0.001).

Abbreviations: AIA, adjuvant-induced arthritis; FA-PPLNPs/Mtx, methotrexate-loaded folic acid–polyethylene glycol–poly(lactic-co-glycolic acid)–poly(cyclohexane-1, 4-diylacetone dimethylene ketal)–lipid nanoparticles; IL, interleukin; TNFα, tumor necrosis factor α.