Table 1.
Composition and characteristics of lipid–polymer nanoparticles
| Batch | Polymer:lipid (w:w) | PLGA:PCADK (w:w) | FA-PEG-PLGA:PLGA (w:w) | Size (nm) | PDI |
|---|---|---|---|---|---|
| 1 | 10:0 | 10:00 | 0:10 | 208.5±0.95 | 0.139±0.012 |
| 2 | 8:2 | 0:10 | 179±3.66 | 0.129±0.019 | |
| 3 | 6:4 | 0:10 | 156.5±4.94 | 0.138±0.028 | |
| 4 | 5:5 | 0:10 | 153.5±1.04 | 0.155±0.022 | |
| 5 | 6:4 | 8:2 | 0:10 | 173.9±3.45 | 0.256±0.03 |
| 6 | 6:4 | 0:10 | 165.6±1.83 | 0.209±0.017 | |
| 7 | 5:5 | 0:10 | 148.8±3.31 | 0.256±0.014 | |
| 8 | 4:6 | 0:10 | 167.6±17.89 | 0.414±0.049 | |
| 9 | 2:8 | 0:10 | 183.50±2.99 | 0.367±0.054 | |
| 10 | 6:4 | 5:5 | 2:8 | 156.2±1.75 | 0.325±0.015 |
| 11 | 4:6 | 150.1±2.5 | 0.265±0.012 | ||
| 12 | 6:4 | 146.7±4.49 | 0.254±0.01 | ||
| 13 | 8:2 | 138.7±1.31 | 0.167±0.006 | ||
| 14 | 10:0 | 133.6±5.07 | 0.173±0.021 |
Note: Data are expressed as mean ± standard deviation.
Abbreviations: PLGA, poly(lactic-co-glycolic acid); PCADK, poly(cyclohexane-1,4-diylacetone dimethylene ketal); FA, folic acid; PEG, polyethylene glycol; PDI, poly dispersity index.