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Effect of chronic Hcy administration on complex-I activity. Mice were treated with Hcy (100 mg/kg or 250 mg/kg) or vehicle daily were sacrificed on 60th day after the last dose and complex-I activity was measured in the (A) nucleus caudatus putamen (NCP) and (B) substantia nigra (SN) region by employing a spectrophotometric procedure using NADH as substrate. Results given are mean±SEM of nmol of NADH oxidized/min/mg protein. *P≤0.05 as compared to control (n=6).
