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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Acta Neuropathol. 2017 May 31;134(1):35–44. doi: 10.1007/s00401-017-1734-6

Figure 3.

Figure 3

Evidence for a complement bystander mechanism for AQP4-IgG / complement-induced oligodendrocyte injury. C5b-9 (a) and C1q (b) immunofluorescence of astrocyte-oligodendrocyte cocultures at 2 hours after incubation with 20 µg/ml AQP4-IgG and 2% human complement. c. Percentage of C5b-9 and C1q positive oligodendrocytes at different distances from C5b-9 or C1q positive astrocytes (mean ± S.E.M., n=6, * P < 0.01 comparing AQP4-IgG vs. control-IgG). d. C3d immunofluorescence of cocultures treated as in panels a and b.