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. Author manuscript; available in PMC: 2018 Oct 1.

Published in final edited form as: Biochim Biophys Acta. 2017 Jul 4;1865(10):1246–1254. doi: 10.1016/j.bbapap.2017.07.001

Table 1.

Substrate sequences that target the thrombin active site ^a

	`P_{9…………}P_4……P_1…`
Factor XIII (28–41) V34 AP	`²⁸TVELQGVVPRGVNL⁴¹`
Factor XIII (28–41) L34 AP	`²⁸TVELQGLVPRGVNL⁴¹`
Factor XIII (28–41) F34 AP	`²⁸TVELQGFVPRGVNL⁴¹`
Factor XIII (28–41) W34AP	`²⁸TVELQGWVPRGVNL⁴¹`
Factor XIII (28–41) Y34 AP	`²⁸TVELQGYVPRGVNL⁴¹`
Factor XIII (28–41) P34 AP	`²⁸TVELQGPVPRGVNL⁴¹`
Fibrinogen Aα (7–20)	`⁷DFLAEGGGVRGPRV²⁰`
Thrombin Receptor PAR1 (32–45)	`³²KATNATLDPRSFLL⁴⁵`
Thrombin Receptor PAR4 (38–51)	`³⁸STPSILPAPRGYPG⁵¹`

^a

Sequences of human FXIII, fibrinogen Aα and Thrombin Receptors (PAR1 and PAR4) are displayed. The residues are aligned along the P₄ position.