Appendix Table 1.
MS Journal Appendix for MRI methodology.
| Hardware | ||
| Field strength | 3T | |
| Manufacturer | Philips | |
| Model | Achieva | |
| Coil type (e.g. head, surface) | Head | |
| Number of coil channels | 8 | |
| Acquisition sequence | ||
| Type (e.g. FLAIR, DIR, DTI, fMRI) | 3D Turbo spin echo | |
| Acquisition time | 7:48 | |
| Orientation | Transverse | |
| Alignment (e.g. anterior commissure/ poster commissure line) | Localized SI along the optic nerve | |
| Voxel size | 0.55 mm isotropic | |
| TR | 4000 ms | |
| TE | 455 ms | |
| TI | N/A | |
| Flip angle | 90° | |
| NEX | 2 | |
| Field of view | 180 × 180 × 20 mm3 | |
| Matrix size | 328 × 328 | |
| Parallel imaging | Yes | No |
| If used, parallel imaging method: (e.g. SENSE, GRAPPA) | SENSE = 2 | |
| Cardiac gating | Yes | No |
| If used, cardiac gating method: (e.g. PPU or ECG) | N/A | |
| Contrast enhancement | Yes | No |
| If used, provide name of contrast agent, dose and timing of scan post- contrast administration | N/A | |
| Other parameters: | Recon Matrix = 512 | |
| TSE factor = 70 | ||
| Turbo direction = radial | ||
| SPIR strength = strong | ||
| Image analysis methods and outputs | ||
| Lesions | ||
| Type (e.g. Gd-enhancing, T2-hyperintense, T1-hypointense) | ||
| Analysis method | ||
| Analysis software | ||
| Output measure (e.g. count or volume [ml]) | ||
| Tissue volumes | ||
| Type (e.g. whole brain, grey matter, white matter, spinal cord) | ||
| Analysis method | ||
| Analysis software | ||
| Output measure (e.g. absolute tissue volume in ml, tissue volume as a fraction of intracranial volume, percentage change in tissue volumes) | ||
| Tissue measures (e.g. MTR, DTI, T1-RT, T2-RT, T2*, T2’, 1H-MRS, perfusion, Na) | ||
| Type (e.g. whole brain, grey matter, white matter, spinal cord, normal- appearing grey matter or white matter) | ||
| Analysis method | ||
| Analysis software | ||
| Output measure | ||
| Other MRI measures (e.g. functional MRI) | ||
| Type (e.g. whole brain, grey matter, white matter, spinal cord, normal- appearing grey matter or white matter) | ||
| Analysis method | ||
| Analysis software | ||
| Output measure | ||
Other analysis details:
FLAIR: fluid-attenuated inversion recovery; DIR: double inversion recovery; DTI: diffusion tensor imaging; fMRI: functional magnetic resonance imaging; 3D: three-dimensional; SI: superior-inferior; TR: repetition time; TE: echo time; TI: inversion time; NEX: number of excitations; SENSE: Sensitivity Encoding; GRAPPA: Generalized Autocalibrating Partial Parallel Acquisition; PPU: peripheral pulse unit; ECG: electrocardiogram; TSE: turbo spin echo; SPIR: spectral presaturation with inversion recovery; Gd: gadolinium; MTR: magnetization transfer ratio; DTI: diffusion tensor imaging; RT: relaxation times; 1H-MRS: proton magnetic resonance spectroscopy; MRI: magnetic resonance imaging; fMRI: functional magnetic resonance imaging.