Table 3.
Adjusted1 mean (95% CI) 24-hour, day-time and night-time peripheral and central blood pressure and pulse wave velocity for MTX and non-MTX groups at baseline and after 8 months.
| Baseline |
p-value | 8 months |
p-value | MTX × visit interaction | p-value for MTX × visit interaction | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| No-MTX(n = 26) | MTX(n = 54) | Adjusted Δ | No-MTX(n = 26) | MTX(n = 54) | Adjusted Δ | |||||
| Peripheral SBP | ||||||||||
| Day | 132 (128, 136) | 127 (124, 130) | −6.8 (−11, −2.8) | <0.001 | 136 (132, 140) | 123 (120, 126) | −13 (−17, −9) | <0.001 | −6 (−8.7, −3.4) | <0.001 |
| Night | 121 (116, 126) | 117 (113, 121) | −4.3 (−9.9, 1.3) | 0.13 | 121 (116, 126) | 116 (112, 120) | −3.5 (−8.9, 2) | 0.21 | 0.8 (−3, 4.7) | 0.67 |
| 24-hour | 129 (125, 133) | 125 (122, 128) | −6.5 (−10, −3) | <0.001 | 133 (129, 137) | 121 (118, 124) | −11 (−15, −7.7) | <0.001 | −4.6 (−6.9, −2.3) | <0.001 |
| Peripheral DBP | ||||||||||
| Day | 77 (75, 79) | 76 (74, 77) | −2.9 (−5.5, −0.3) | 0.03 | 78 (75, 80) | 72 (70, 74) | −5.7 (−8.2, −3.2) | <0.001 | −2.8 (−4.6, −1.0) | 0.003 |
| Night | 68 (65, 71) | 68 (66, 70) | −1.9 (−5.6, 1.7) | 0.30 | 69 (66, 72) | 67 (65, 69) | −1.6 (−5.2, 2.1) | 0.40 | 0.4 (−2.5, 3.2) | 0.81 |
| 24-hour | 75 (73, 77) | 74 (72, 75) | −2.8 (−5.2, −0.5) | 0.02 | 76 (73, 78) | 71 (69, 73) | −5.1 (−7.3, −2.8) | <0.001 | −2.1 (−3.8,−0.6) | 0.006 |
| Central SBP | ||||||||||
| Day | 120 (117, 124) | 117 (115, 120) | −4.2 (−7.8, −0.6) | 0.02 | 124 (120, 127) | 113 (110, 116) | −10 (−14, −6.7) | <0.001 | −6.1 (−8.5, −3.7) | <0.001 |
| Night | 112 (107, 117) | 110 (106, 113) | −2.7 (−8.1, 2.7) | 0.33 | 113 (108, 118) | 108 (104, 112) | −3.7 (−9, 1.6) | 0.18 | −1.0 (−4.9, 3.0) | 0.64 |
| 24-hour | 118 (115, 122) | 116 (113, 118) | −3.7 (−7, −0.4) | 0.03 | 121, (118, 125) | 112 (109, 115) | −8.8 (−12, −5.5) | <0.001 | −5.1 (−7.2, −2.9) | <0.001 |
| Central DBP | ||||||||||
| Day | 79 (77, 82) | 77 (76, 79) | −3.4 (−5.9, −0.8) | 0.01 | 80 (78, 83) | 74 (72, 76) | −6.2 (−8.7, −3.7) | <0.001 | −2.8 (−4.6, −1.1) | 0.002 |
| Night | 69 (66, 72) | 69 (67, 71) | −1.5 (−5.1, 2.2) | 0.43 | 70 (67, 73) | 68 (66, 70) | −1.7 (−5.3, 1.9) | 0.35 | −0.25 (−3.2, 2.7) | 0.87 |
| 24-hour | 77 (75, 79) | 75 (74, 77) | −3 (−5.3, −0.8) | 0.009 | 78 (76, 80) | 73 (71, 74) | −5.4 (−7.7, −3.1) | <0.001 | −2.4 (−3.9, −0.8) | 0.003 |
| PWV | ||||||||||
| Day | 9.3 (9.1, 9.4) | 9.0 (9.0, 9.1) | −0.2 (−0.3, −0.1) | 0.003 | 10.0 (9.8, 10.2) | 8.8 (8.7, 8.9) | −0.4 (−0.6, −0.3) | <0.001 | −0.2 (−0.3, −0.1) | <0.001 |
| Night | 8.9 (8.7, 9.2) | 8.8 (8.6, 8.9) | −0.1 (−0.3, 0.1) | 0.16 | 9.7 (9.5, 9.9) | 8.6 (8.5, 8.8) | −0.2 (−0.4, 0.01) | 0.06 | −0.1 (−0.2, 0.1) | 0.57 |
| 24-hour | 9.2 (9.0, 9.4) | 9.0 (8.8, 9.1) | −0.2 (−0.3, −0.1) | 0.002 | 9.9 (9.8, 10.0) | 8.8 (8.6, 8.9) | −0.4 (−0.5, −0.2) | <0.001 | −0.2 (−0.3, −0.1) | <0.001 |
1
Adjusted for visit, methotrexate use, hour, age, gender, BMI, DAS28 and folic acid use.
DBP, diastolic blood pressure; MTX, methotrexate; PWV, pulse wave velocity; SBP, systolic blood pressure.